New publication from the Greenberg lab is now online at the Molecular Biology of the Cell (here). This work, led by first author Dr. Samantha Barrick, examines a variant in troponin T associated with pediatric onset dilated cardiomyopathy. We show that this variant causes molecular and cellular alterations consistent with those seen in known pathogenic variants. We show that the molecular mechanism driving the early disease pathogenesis is reduced coupling between calcium binding to troponin C and thin filament activation. This in turn leads to changes in cellular contractility and sarcomeric organization.
The preprint, describing our collaborative project with the labs of Samantha Harris, Stuart Campbell, and Jonathan Kirk can be found here.
See the cover here.
Our new publication determined the initial molecular insult driving the disease pathogenesis in a hypertrophic cardiomyopathy mutant and how the insult drives the activation of downstream adaptive pathways. This is a collaboration with Jeanne Nerbonne's lab. The paper can be found here. Congratulations to Sarah, Paige, David, Lina, Tom, Eve, and Jeanne.
https://pubmed.ncbi.nlm.nih.gov/33248132/ Congratulations to Tommy, Tom, an Sarah.