Welcome to the Greenberg Lab

Our lab is interested in understanding molecular motors and their roles in health and disease. We are particularly interested in cardiovascular diseases, including heart failure and familial cardiomyopathies.  We are interested in understanding the mechanisms driving these diseases and leveraging these mechanistic insights into the development of precision medicine therapeutics. To do this, the lab uses an array of biochemical, biophysical, cell biological, computational, and engineering techniques to decipher how disease-causing perturbations affect contractility across scales from the level of single molecules to the level of engineered tissues. For more details on our research, click here.

New Greenberg lab publication

In collaboration with the Leinwand and Bowman labs, we show that the dynamics of myosin play a critical role in determining drug specificity.  The paper can be found here.  Congratulations to all of the...

New Greenberg lab preprint looking at how the cardiac myosin working stroke is modulated by the thin filament

Human heart contraction is powered by the molecular motor β-cardiac myosin, which pulls on thin filaments consisting of actin and the regulatory proteins troponin and tropomyosin. In some muscle and non-muscle systems, these regulatory proteins tune the kinetics,...

New Greenberg Lab publication in collaboration with the Geeves, Bowman, and Leinwand labs

Here, we examined how the sarcomeric myosin MYH7b is structurally, mechanically, and kinetically tuned for its unique role in specialized muscles. Publication can be found here....

New collaborative preprint between the Greenberg, Bowman, and Leinwand labs examining the how drugs target specific myosin isoforms.

Specific myosin isoforms have emerged as drug targets in diseases including heart failure, cancer, muscle diseases, and parasitic infections; however, targeting specific myosins without affecting others has been challenging since most myosins share a common...

Brent Scott joins the lab

The Greenberg lab welcomes Brent Scott, PhD as a new postdoc in the lab.

Greenberg lab receives a new collaborative grant from the AHA

The Greenberg lab, together with collaborators Kory Lavine and Nate Huebsch, received a Transformational Project Award entitled “Human heart-on-a-chip to study the immune system in cardiac disease pathogenesis and repair”.

Greenberg lab presents at AHA BCVS

Ankit Garg presented his data at the American Heart Association BCVS meeting: P1059 / P1059 – Establishing The Mechanistic Basis Of Dilated Cardiomyopathy Associated With The Skeletal Muscle Actin Mutation R256H.

New Greenberg lab collaborative publication on tropomyosin mutations in myopathies and birth defects

In collaboration with the Gurnett and Johnson labs, we looked at pathogenic mutations in tropomyosin that cause various forms of skeletal myopathies and birth defects. McAdow J, Yang S, Ou T, Huang G, Dobbs MB, Gurnett CA, Greenberg MJ, Johnson AN. A pathogenic...

Greenberg lab and friends present at BPS 2022

The Greenberg lab had 4 presentations at BPS 2022: Platform (Samantha Barrick – Postdoc): STRUCTURAL DIFFERENCES IN VINCULIN AND METAVINCULIN ACTIN-BINDING DOMAINS EXPLORED BY MOLECULAR DYNAMICS SIMULATIONS Poster (Jeff Lotthammer – Student Bowman lab):...

Greenberg lab presents at ASCB 2021

The Greenberg lab had 2 posters as ASCB 2021: Dr. Samantha Barrick presented a poster: A Troponin T Variant Linked with Pediatric Dilated Cardiomyopathy Decreases Cardiac Contractility by Reducing the Coupling of Thin Filament Activation to Myosin and Calcium Binding...