Our lab is interested in understanding molecular motors and their role in mechanobiology. Currently, the lab is studying mutations in contractile proteins that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The presentation and prognosis in patients depends on the exact mutation, and therefore these diseases are excellent candidates for a precision medicine approach.
The lab uses an array of biochemical, biophysical, cell biological, and engineering techniques to decipher how these mutations affect the mechanobiology of heart contraction across scales from the level of single molecules to the level of engineered tissues. We then use computational modeling to link these scales. For our molecular studies, we have developed an optical trap with fast feedback to study the contractility of single molecules. For our cellular and tissue-level studies, we use genetic and tissue engineering to develop human stem cell-based models of the disease. We are using insights gleaned from our studies to develop novel therapies.
Recent Lab News
- New preprint on the BioRxiv (in collaboration with the Bowman lab) describing molecular dynamics simulations for predicting the biochemistry of diverse myosin isoforms December 17, 2019
- The Greenberg lab presents data at the ASCB meeting December 8, 2019
- Sami presents his data at the MCMS Undergraduate Research Symposium November 16, 2019
- Sami presents his data at the Undergraduate Research Symposium November 4, 2019
- Lab outing to celebrate the latest paper November 1, 2019
- Sarah presents her data at Cardiovascular Research Day October 10, 2019
- Sami selected to present at the MCMS Undergraduate Research Symposium at the University of Chicago October 2, 2019
- Sarah receives the Elliot Elson Fellowship September 27, 2019
- Jackie attends the Myology Meeting in Columbus August 26, 2019
- New publication: Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy. Published in Proceedings of the National Academy of Sciences August 19, 2019