Our lab is interested in understanding molecular motors and their role in mechanobiology. Currently, the lab is studying mutations in contractile proteins that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The presentation and prognosis in patients depends on the exact mutation, and therefore these diseases are excellent candidates for a precision medicine approach.
The lab uses an array of biochemical, biophysical, cell biological, and engineering techniques to decipher how these mutations affect the mechanobiology of heart contraction across scales from the level of single molecules to the level of engineered tissues. We then use computational modeling to link these scales. For our molecular studies, we have developed an optical trap with fast feedback to study the contractility of single molecules. For our cellular and tissue-level studies, we use genetic and tissue engineering to develop human stem cell-based models of the disease. We are using insights gleaned from our studies to develop novel therapies.
Recent Lab News
- New Greenberg lab publication on the molecular and cellular basis of a hypertrophic cardiomyopathy mutation April 15, 2021
- Samantha received an F32 NRSA Fellowship April 15, 2021
- New paper on modeling the effects of SARS-CoV-2 on the heart February 27, 2021
- New publication with Jil Tardiff on complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine January 29, 2021
- Our paper describing new single molecule tools is now in press at Biophysical Journal. January 1, 2021
- New Greenberg lab collaborative publication on engineering models SARS-CoV-2 myocarditis November 5, 2020
- Michael was a guest on the AJP podcast October 16, 2020
- New Greenberg lab publication on precision medicine for heart failure September 3, 2020
- New Greenberg lab publication on the BioRxiv describing our computational tool for analyzing single molecule data August 10, 2020
- New Greenberg lab publication in eLife on myosin motors June 1, 2020