Our lab is interested in understanding molecular motors and their role in mechanobiology. Currently, the lab is studying mutations in contractile proteins that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The presentation and prognosis in patients depends on the exact mutation, and therefore these diseases are excellent candidates for a precision medicine approach.
The lab uses an array of biochemical, biophysical, cell biological, and engineering techniques to decipher how these mutations affect the mechanobiology of heart contraction across scales from the level of single molecules to the level of engineered tissues. We then use computational modeling to link these scales. For our molecular studies, we have developed an optical trap with fast feedback to study the contractility of single molecules. For our cellular and tissue-level studies, we use genetic and tissue engineering to develop human stem cell-based models of the disease. We are using insights gleaned from our studies to develop novel therapies.
Recent Lab News
- Jackie attends the Myology Meeting in Columbus August 26, 2019
- New publication: Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy. Published in Proceedings of the National Academy of Sciences August 19, 2019
- Greenberg lab receives a grant from the Children’s Discovery Institute to study pediatric heart failure August 1, 2019
- Greenberg lab presents their data at the AHA BCVS meeting July 28, 2019
- Greenberg lab outing July 10, 2019
- New Publication in Biophysical Journal: Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease May 29, 2019
- Sami receives a BioSURF fellowship April 8, 2019
- Sarah and Sam present their work at the Biophysical Society Annual Meeting March 7, 2019
- New preprint from the Greenberg Lab – Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy February 21, 2019
- New preprint from the Greenberg Lab – Computational tool to study perturbations in muscle regulation and its application to heart disease February 21, 2019