Welcome to the Greenberg Lab
Our lab is interested in understanding molecular motors and their roles in health and disease. We are particularly interested in cardiovascular diseases, including heart failure and familial cardiomyopathies. We are interested in understanding the mechanisms driving these diseases and leveraging these mechanistic insights into the development of precision medicine therapeutics. To do this, the lab uses an array of biochemical, biophysical, cell biological, computational, and engineering techniques to decipher how disease-causing perturbations affect contractility across scales from the level of single molecules to the level of engineered tissues. For more details on our research, click here.
Dr. Garg, a postdoc in the lab started a new position at Johns Hopkins and received a great score on his K08 grant from NHLBI!
Our latest publication is “Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas”. Here, we describe how experimental and computational biophysical tools are being harnessed to study cardiomyopathies and how they...
New article with Dr. Ankit Garg, “Assessing Cardiac Contractility From Single Molecules to Whole Hearts”. We describe how multiscale tools can be harnessed to reveal new insights into heart failure. The article can be found...
Dr. Ankit Garg won the Sobel Award for Basic and Translational...
This work, lead by first authors Sarah Clippinger-Schulte and Brent Scott, shows that regulatory proteins in cardiac muscle act via a steric blocking mechanism at physiological ATP concentrations. These proteins do not affect myosin’s mechanics or load...
The Greenberg lab has a new collaborative publication with the Geeves and Leinwand labs. We examined mutations in the myosin MYH7b associated with hearing loss. The paper includes optical trapping by Dr. Samantha Barrick using our new fast feedback system designed...
Brent Scott was appointed to the Pediatric Cardiopulmonary T32.
In collaboration with the Lin and Stitziel labs, we applied our biophysical tools to study a de novo variant found in a patient with heart failure. We show how these tools can be used to provide insights into the potential pathogenicity of rare variants and harnessed...
In collaboration with the Leinwand and Bowman labs, we show that the dynamics of myosin play a critical role in determining drug specificity. The paper can be found here. Congratulations to all of the...