Our lab is interested in understanding molecular motors and their role in mechanobiology. Currently, the lab is studying mutations in contractile proteins that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The presentation and prognosis in patients depends on the exact mutation, and therefore these diseases are excellent candidates for a precision medicine approach.
The lab uses an array of biochemical, biophysical, cell biological, and engineering techniques to decipher how these mutations affect the mechanobiology of heart contraction across scales from the level of single molecules to the level of engineered tissues. We then use computational modeling to link these scales. For our molecular studies, we have developed an optical trap with fast feedback to study the contractility of single molecules. For our cellular and tissue-level studies, we use genetic and tissue engineering to develop human stem cell-based models of the disease. We are using insights gleaned from our studies to develop novel therapies.
Recent Lab News
- Greenberg lab and friends present at BPS 2022 February 27, 2022
- Greenberg lab presents at ASCB 2021 December 1, 2021
- New Greenberg lab publication on cardiac myosin October 12, 2021
- New Greenberg lab collaborative publication on diabetic heart failure September 9, 2021
- Congratulations Dr. Schulte, the first PhD from the Greenberg lab! August 30, 2021
- New Greenberg lab collaborative publication on how resident cardiac macrophages mediate adaptive myocardial remodeling July 27, 2021
- New Greenberg lab publication on pediatric dilated cardiomyopathy from Dr. Barrick June 24, 2021
- New collaborative Greenberg lab preprint on diabetic heart failure June 15, 2021
- Greenberg lab highlighted on the cover of the Journal of General Physiology May 3, 2021
- New Greenberg lab publication on the molecular and cellular basis of a hypertrophic cardiomyopathy mutation April 15, 2021