Lab News

New collaborative preprint between the Greenberg, Bowman, and Leinwand labs examining the how drugs target specific myosin isoforms.

Specific myosin isoforms have emerged as drug targets in diseases including heart failure, cancer, muscle diseases, and parasitic infections; however, targeting specific myosins without affecting others has been challenging since most myosins share a common structure.  Here, we show that the structural dynamics play a critical role in determining drug specificity. The understandings gleaned from this study will help with the design of new therapeutics targeting specific myosin isoforms.

To read the paper, click here.

Greenberg lab presents at AHA BCVS

Ankit Garg presented his data at the American Heart Association BCVS meeting: P1059 / P1059 – Establishing The Mechanistic Basis Of Dilated Cardiomyopathy Associated With The Skeletal Muscle Actin Mutation R256H.

New Greenberg lab collaborative publication on tropomyosin mutations in myopathies and birth defects

In collaboration with the Gurnett and Johnson labs, we looked at pathogenic mutations in tropomyosin that cause various forms of skeletal myopathies and birth defects.

McAdow J, Yang S, Ou T, Huang G, Dobbs MB, Gurnett CA, Greenberg MJ, Johnson AN. A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2 directed myogenesis. JCI Insight. 2022 May 17:e152466. doi: 10.1172/jci.insight.152466. Epub ahead of print. PMID: 35579956.

Greenberg lab and friends present at BPS 2022

The Greenberg lab had 4 presentations at BPS 2022:

Platform (Samantha Barrick – Postdoc): STRUCTURAL DIFFERENCES IN VINCULIN AND METAVINCULIN ACTIN-BINDING DOMAINS EXPLORED BY MOLECULAR DYNAMICS SIMULATIONS

Poster (Jeff Lotthammer – Student Bowman lab): EXPLORING THE MYOSIN ACTIVE/AUTO-INHIBITED STATE EQUILIBRIUM BY MARKOV STATE MODELING

Poster (Artur Meller – Student Bowman lab): SIGNATURES OF ALLOSTERIC MODULATOR SPECIFICITY ARE ENCODED IN MYOSIN MOTOR DOMAIN EQUILIBRIUM FLUCTUATIONS

Poster (Michael Greenberg – PI): HARNESSING MULTISCALE MODELS OF A DILATED CARDIOMYOPATHY MUTATION FOR PRECISION MEDICINE

Greenberg lab presents at ASCB 2021

The Greenberg lab had 2 posters as ASCB 2021:

Dr. Samantha Barrick presented a poster: A Troponin T Variant Linked with Pediatric Dilated Cardiomyopathy Decreases Cardiac Contractility by Reducing the Coupling of Thin Filament Activation to Myosin and Calcium Binding

And Michael Greenberg presented: Utilizing Multiscale Models of a Dilated Cardiomyopathy Mutation for Precision Medicine, which included collaborative work from the Lavine lab.

New Greenberg lab publication on cardiac myosin

This article, co-authored with Dr. Samantha Barrick, focuses on cardiac myosin, highlighting new regulatory mechanisms, its roles beyond sarcomeric contraction, its emergence as a drug target, and some outstanding questions for the field.
The article can be found here.