Welcome to the Greenberg Lab

Our lab is interested in understanding molecular motors and their roles in health and disease. We are particularly interested in cardiovascular diseases, including heart failure and familial cardiomyopathies.  We are interested in understanding the mechanisms driving these diseases and leveraging these mechanistic insights into the development of precision medicine therapeutics. To do this, the lab uses an array of biochemical, biophysical, cell biological, computational, and engineering techniques to decipher how disease-causing perturbations affect contractility across scales from the level of single molecules to the level of engineered tissues. For more details on our research, click here.

New Greenberg lab publication in PNAS, lead by Dr. Ankit Garg

Skeletal muscle actin mutations are well known to cause skeletal myopathies, but their role in cardiomyopathies has been controversial as skeletal muscle actin is only expressed at modest levels in the heart. Here, we demonstrate that a skeletal muscle actin mutation...

New collaborative publication on pediatric pneumococcal disease

This was a fun collaboration, lead by the Morley lab.  Congratulations to all of the authors! The paper can be found here.

New preprint from the Greenberg lab on the molecular mechanism of danicamtiv

Congratulations to first author, Dr. Brent Scott, and our collaborators at the University of Kentucky, Drs. Caterina Squari and Ken Campbell.  We show that although danicamtiv was originally described as a myosin activator, its molecular mechanism is more complicated,...

Congratulations Brent!

Congratulations to Brent Scott for winning the BMB Postdoctoral Research Discovery and Innovation...

New preprint from our lab in collaboration with the Hlehouse and Soranno labs examining the troponin-T linker region that is a hotspot for cardiomyopathy mutations and variants of unknown significance.

Together, we used single molecule techniques, in vitro reconstitution assays, and molecular dynamics simulations to demonstrate that this linker region is intrinsically disordered and dynamic in the context of isolated troponin and the fully-regulated thin filament. ...

Ella Mozier joins the lab as a graduate student

Welcome to Ella Mozier, a new graduate student in the lab who will be co-mentored with Andrea Soranno.

New Greenberg lab preprint in collaboration with the Garcia and Lavine labs

Familial dilated cardiomyopathy (DCM) is frequently caused by autosomal dominant point mutations in genes involved in diverse cellular processes, including sarcomeric contraction. While patient studies have defined the genetic landscape of DCM, genetics are not...

New Greenberg lab publication, lead by Dr. Ankit Garg, looking at mutations in skeletal muscle actin causing cardiomyopathy

Skeletal muscle actin mutations are well-known to cause skeletal myopathies, but their role in cardiomyopathies have been controversial as skeletal muscle actin is only expressed at modest levels in the heart.  Here, we demonstrate that a skeletal muscle actin...

New collaborative Greenberg Lab publication with the Hinson lab on titin truncation variants

Congratulations to all of the authors.  The publication can be found here.