Welcome to the Greenberg Lab
Our lab is interested in understanding molecular motors and their roles in health and disease. We are particularly interested in cardiovascular diseases, including heart failure and familial cardiomyopathies. We are interested in understanding the mechanisms driving these diseases and leveraging these mechanistic insights into the development of precision medicine therapeutics. To do this, the lab uses an array of biochemical, biophysical, cell biological, computational, and engineering techniques to decipher how disease-causing perturbations affect contractility across scales from the level of single molecules to the level of engineered tissues. For more details on our research, click here.
Familial dilated cardiomyopathy (DCM) is frequently caused by autosomal dominant point mutations in genes involved in diverse cellular processes, including sarcomeric contraction. While patient studies have defined the genetic landscape of DCM, genetics are not...
Skeletal muscle actin mutations are well-known to cause skeletal myopathies, but their role in cardiomyopathies have been controversial as skeletal muscle actin is only expressed at modest levels in the heart. Here, we demonstrate that a skeletal muscle actin...
The preprint can be found here. Thank you to Gretchen Meyer and our other collaborators for including us.
Congratulations to all of the authors. The publication can be found here.
Dr. Garg, a postdoc in the lab started a new position at Johns Hopkins and received a great score on his K08 grant from NHLBI!
Our latest publication is “Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas”. Here, we describe how experimental and computational biophysical tools are being harnessed to study cardiomyopathies and how they...
New article with Dr. Ankit Garg, “Assessing Cardiac Contractility From Single Molecules to Whole Hearts”. We describe how multiscale tools can be harnessed to reveal new insights into heart failure. The article can be found...
Dr. Ankit Garg won the Sobel Award for Basic and Translational...
This work, lead by first authors Sarah Clippinger-Schulte and Brent Scott, shows that regulatory proteins in cardiac muscle act via a steric blocking mechanism at physiological ATP concentrations. These proteins do not affect myosin’s mechanics or load...
The Greenberg lab has a new collaborative publication with the Geeves and Leinwand labs. We examined mutations in the myosin MYH7b associated with hearing loss. The paper includes optical trapping by Dr. Samantha Barrick using our new fast feedback system designed...