Greenberg lab receives a new collaborative grant from the AHA
The Greenberg lab, together with collaborators Kory Lavine and Nate Huebsch, received a Transformational Project Award entitled “Human heart-on-a-chip to study the immune system in cardiac disease pathogenesis and repair”.
Greenberg lab presents at AHA BCVS
Ankit Garg presented his data at the American Heart Association BCVS meeting: P1059 / P1059 – Establishing The Mechanistic Basis Of Dilated Cardiomyopathy Associated With The Skeletal Muscle Actin Mutation R256H.
New Greenberg lab collaborative publication on tropomyosin mutations in myopathies and birth defects
In collaboration with the Gurnett and Johnson labs, we looked at pathogenic mutations in tropomyosin that cause various forms of skeletal myopathies and birth defects.
Greenberg lab and friends present at BPS 2022
The Greenberg lab had 4 presentations at BPS 2022:
Platform (Samantha Barrick – Postdoc): STRUCTURAL DIFFERENCES IN VINCULIN AND METAVINCULIN ACTIN-BINDING DOMAINS EXPLORED BY MOLECULAR DYNAMICS SIMULATIONS
Poster (Jeff Lotthammer – Student Bowman lab): EXPLORING THE MYOSIN ACTIVE/AUTO-INHIBITED STATE EQUILIBRIUM BY MARKOV STATE MODELING
Poster (Artur Meller – Student Bowman lab): SIGNATURES OF ALLOSTERIC MODULATOR SPECIFICITY ARE ENCODED IN MYOSIN MOTOR DOMAIN EQUILIBRIUM FLUCTUATIONS
Poster (Michael Greenberg – PI): HARNESSING MULTISCALE MODELS OF A DILATED CARDIOMYOPATHY MUTATION FOR PRECISION MEDICINE
Greenberg lab presents at ASCB 2021
The Greenberg lab had 2 posters as ASCB 2021:
Dr. Samantha Barrick presented a poster: A Troponin T Variant Linked with Pediatric Dilated Cardiomyopathy Decreases Cardiac Contractility by Reducing the Coupling of Thin Filament Activation to Myosin and Calcium Binding
And Michael Greenberg presented: Utilizing Multiscale Models of a Dilated Cardiomyopathy Mutation for Precision Medicine, which included collaborative work from the Lavine lab.
New Greenberg lab publication on cardiac myosin
This article, co-authored with Dr. Samantha Barrick, focuses on cardiac myosin, highlighting new regulatory mechanisms, its roles beyond sarcomeric contraction, its emergence as a drug target, and some outstanding questions for the field.
The article can be found here.
New Greenberg lab collaborative publication on diabetic heart failure
In collaboration with the labs of Drs. Samantha Harris, Stuart Campbell, and Jonathan Kirk, the Greenberg lab published a paper on actomyosin dysfunction in diabetic heart failure. Congratulations to Dr. Samantha Barrick and our collaborators. The publication can here.
Congratulations Dr. Schulte, the first PhD from the Greenberg lab!
Congratulations to Dr. Sarah Clippinger Schulte for successfully defending her thesis. Dr. Schulte is the first Greenberg lab graduate student to receive their PhD.
New Greenberg lab collaborative publication on how resident cardiac macrophages mediate adaptive myocardial remodeling
A new publication in Immunity, including Greenberg lab contributions can be found here. This work stems from one of our long-standing collaborations with the Lavine lab. Congratulations to all of our co-authors.